Undifferentiated sarcomas in humans and veterinary species

Undifferentiated sarcomas, more correctly known as undifferentiated pleomorphic sarcomas (UPS), are a form of soft tissue sarcoma. They appear to be uncommonly diagnosed in veterinary species but represent the second most common sarcoma human adults. There is an evolving nomenclature around these tumours, with older reports referring ‘malignant fibrous histiocytoma’, have been reclassified into several different tumour types, including UPS. This makes review literature challenging, many tumours previously referred malignant histiocytomas and not same En bloc surgical excision mainstay treatment all species, although adjunctive radiotherapy perioperative chemotherapy improve prognosis humans, should considered horses this type. Metastasis uncommon can devastating when it occurs.